KEGG   DRUG: Phendimetrazine
Entry
D08347                      Drug                                   
Name
Phendimetrazine (INN)
Formula
C12H17NO
Exact mass
191.131
Mol weight
191.2695
Structure
Simcomp
Class
Neuropsychiatric agent
 DG03085  Selective norepinephrine reuptake inhibitor (NRI)
Gastrointestinal agent
 DG01705  Anoretic
  DG01704  Phenethylamine anorexic
Remark
Same as: C07904
Chemical structure group: DG01537
Product (DG01537): D02080<US>
Efficacy
Appetite suppressant (systemic), Stimulant (central)
Comment
Active form of prodrug: Phenmetrazine [CPD:C07432]
Morpholine derivative
Target
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
  Pathway
hsa04721  Synaptic vesicle cycle
Interaction
Brite
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG03085  Selective norepinephrine reuptake inhibitor (NRI)
   DG01537  Phendimetrazine
    D08347  Phendimetrazine
 Gastrointestinal agent
  DG01705  Anoretic
   DG01704  Phenethylamine anorexic
    DG01537  Phendimetrazine
     D08347  Phendimetrazine
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D08347  Phendimetrazine (INN)
Narcotics and psychotropics in Japan [br08308.html]
 Psychotropics by Cabinet order Article 3 (78 substances)
  D08347
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG03085  Selective norepinephrine reuptake inhibitor (NRI)
   DG01537  Phendimetrazine
 Gastrointestinal agent
  DG01705  Anoretic
   DG01704  Phenethylamine anorexic
    DG01537  Phendimetrazine
Other DBs
CAS: 634-03-7
PubChem: 96025034
ChEBI: 8059
LigandBox: D08347
NIKKAJI: J6.905A
KCF data

ATOM        14
            1   C8x C    15.3300  -27.5100
            2   C8x C    15.3300  -28.9100
            3   C8x C    16.5424  -29.6100
            4   C8x C    17.7549  -28.9100
            5   C8y C    17.7549  -27.5100
            6   C8x C    16.5424  -26.8100
            7   C1y C    18.9860  -26.7990
            8   C1y C    20.1912  -27.4947
            9   N1y N    21.4035  -26.7946
            10  C1x C    21.4035  -25.3946
            11  C1x C    20.1983  -24.6989
            12  O2x O    18.9859  -25.3990
            13  C1a C    22.6351  -27.5054
            14  C1a C    20.1916  -28.9096
BOND        15
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   5 1 #Down
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13    7  12 1
            14    9  13 1
            15    8  14 1 #Up

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